Santa Fe is one of those places people love to say is "over." No problem. More room for me. Though Santa Fe has definitely moved beyond its early days of laidback, southwestern charm, it remains a fantastic destination. Great food, lots of art, a beautiful setting, proximity to an incredible region of high altitude natural beauty, and culture for days, including the Santa Fe Opera and Santa Fe Chamber Music Festival. Oh, and a bit of a gay scene to boot.
There are a lot of great, pricey and worth-the-price hotels here. But I've stayed at a simple but wonderful B&B called El Paradero, where few rooms will cost you more than $150 a night, including a gourmet breakfast that'll blow you away. It's built in an 1820's adobe farmhouse, and is just a short walk to the center of town. Get a room with an adobe fireplace, if available. Even in the summer. While you're in Santa Fe, be sure to pay at least one visit to the absolutely sublime Japanese spa called 10,000 Waves. Oh, and my favorite restaurant (though I haven't been in a few years) is Geronimo.